139 / 2019-11-05 19:37:26

Nephrolithiasis, Influencing Factors and Risk of Developing Cardiovascular Disease: Systematic Review and Meta-Analysis.

Kidney stones, Nephrolithiasis, Cardiovascular disease, Systematic review, Meta-analysis.

Nephrolithiasis, Influencing Factors and Risk of Developing Cardiovascular Disease: Systematic Review and Meta-Analysis.
Kwabena Acheampong1,2, Xiongfeng Pan1, *Aizhong Liu1
1 Department of Epidemiology and Health Statistics, Xiangya School of Public Central South University, Changsha Hunan, 410078, China. ‡Department of Public Health, Adventist University of Africa, Kenya

Abstract

Nephrolithiasis is associated with high systemic arterial blood pressure, hyperglycemia, glucose intolerance, atherosclerotic plaques, kidney function decline, and increased cardiovascular (CV) events. We decided to examine the association between nephrolithiasis and risk of CVD morbidity via a systematic review and meta-analysis. We included twelve observational studies published from inception to 2018, including more than four million participants. A total of 12 articles containing 24 results participants were finally acknowledged in this meta-analysis. The shared prevalence of nephrolithiasis was 16.6% across studies. The common risk factors of nephrolithiasis were genders, chronic kidney disease, hypertension, diabetes, obesity, dyslipidemia, gout, alcohol dependence, hyperlipidemia, chronic obstructive pulmonary disease and less physically active. The pooled risk ratio (RR) of patients with nephrolithiasis who experienced CVD was 1.26(95% Cl, 1.18-1.34, p≤0.01), with substantial heterogeneity between these analyses (I2=84.31%, p≤0.01). Nephrolithiasis is strongly associated with an increased risk of CVD.