124 / 2019-11-04 20:04:57

Association between gene polymorphisms of vitamin D receptor and gestational diabetes mellitus: a systematic review and meta-analysis

Vitamin D receptor gene polymorphism,Gestational diabetes mellitus,Systematic review,meta-analysis

Background:The relationship between Vitamin D receptor(VDR) gene polymorphism and gestational diabetes mellitus(GDM) in studies are inconsistent. The aim of this study was to investigate association between the polymorphisms of VDR genes and the susceptibility of GDM.
Methods: We searched databases of PubMed、Web of science、Embase、CNKI、VIP and Wanfang Data for relevant articles. A systematic review and meta-analysis were done to compare the distribution of VDR gene polymorphism in GMD patients with those in controls by using allelic、co-dominant、dominant and recessive models.
Results: A total of 99 articles were identified and finally 6 of them were included. The SNPs of rs7975232、rs1544410、rs2228570 and rs731236 with 883 GDM patients and 1115 controls in all were analyzed. Our results showed that there were no correlations between VDR genes rs1544410( 5 articles were included)、rs2228570( 3 articles were included)、rs731236( 4 articles were included) and GDM in neither four models. While VDR gene rs7975232 polymorphism（3 articles were included) was correlated with GDM significantly under allelic model(OR=1.28,95%CI-1.06~1.56,p=0.0117) 、co-dominant model(CCvsAA OR=1.96, 95%CI-1.26~3.04,P=0.027) and recessive model(OR=1.83,95%CI-1.21~2.76,p=0.0045). Further analysis found that highly heterogeneity existed among studies about VDR gene rs1544410、rs2228570 in all models and rs731236 in some part of models. The sources of heterogeneity were mainly published year、study design 、race、diagnostic criteria and whether match or not.
Conclusion: The evidence of this systematic review and meta-analysis prompted that VDR gene polymorphism of rs7975232 might be the genetic susceptibility factor of GDM. This might provide a new way to find pregnant women who are GDM susceptible so that we can take targeted preventive measures for them. More studies need to be conducted in a standardized way in the future.