108 / 2019-10-31 09:59:24

Association between the serum uric acid and H-type hypertension in urban and rural communities hypertensive patients: a cross-sectional study from Hunan

serum uric acid,,H-type hypertension,hypertensive patients,cross-sectional study

B. 公共卫生相关主题 > Track - B 默认专题

There was limited epidemic data concerning the association of serum uric acid and H-type hypertension. This study aimed to accurately explore the real association between the serum uric acid and H-type hypertension in Chinese hypertensive patients. A total of 1538 hypertensive patients (766 men and 772 women) were recruited from rural and urban communities in Hunan Province. Data on general demographic characteristics (gender, age, BMI, drinking history, education background, etc) were collected in interviews, blood biochemical indicators of all participants (Cr, UA, TG, TC, Hcy, etc) were tested by well-trained experimental personnel in the laboratory, meanwhile, participants underwent accurate assessment of blood pressure. The result of three models for adjusting different confounding factors showed that serum uric acid was a independent risk factor for H-type hypertension, for each SD increase, the risk of H-type hypertension were 1.45 (95% CI: 1.25-1.68 P<0.001), 1.58 (95% CI: 1.34-1.87 P<0.001), 1.42 (95% CI: 1.15-1.75 P=0.001). More importantly, it was found that the risk of developing H-type hypertension was greater with the increase of serum uric acid concentration (P for trend <0.001, <0.001, =0.003). The association between the serum uric acid and H-type hypertension was non-linear. Within a certain range, serum uric acid was an independent risk factor for H-type hypertension, as the serum uric acid concentration increased, the risk of developing H-type hypertension increased. When serum uric acid concentration exceeded 432 μmol/L, it did not affect H-type hypertension.