The outbreak of a disease is determined by interactions between the host, its environment and the pathogen. This “disease triangle” model has been used to predict epidemics in humans as well as in agricultural plants. Because plants are sessile organisms, every aspect of the plant physiology, including immunity against pathogens, is influenced by the environmental conditions, such as light, temperature, and humidity. Moreover, in the absence specialized immune cells, plant defense occurs in coordination with plant growth. In my talk, I will discuss the intricate interconnections between the circadian clock and plant immune mechanisms. I will then show how circadian clock integrates environmental signals in timing as well as gating immune responses to protect against infection while avoiding conflicts with growth-related activities.