714 / 2019-05-07 16:10:03

m6A RNA Modification in Arabidopsis

RNA modification,Arabidopsis

全体主题 > RNA Biology

N6-methyladenosine (m6A) is the most prevalent internal modification on eukaryotic mRNA. Despite the progress in understanding m6A mostly in cell line systems, molecular mechanisms of m6A role in the development of multicellular organisms remain largely unknown. Embryonic lethality resulting from loss of function of m6A methyltransferase complexes is a key bottleneck that prevents the investigation of m6A function in multicellular organisms. By now it is largely unknown how the components in the plant m6A methyltransferase complex sculpt the global m6A mRNA modification landscape, and how their functions in m6A mRNA modification contribute to molecular control of plant development. Here I will discuss how FKBP12 INTERACTING PROTEIN 37 KD (FIP37), a core component of the plant m6A methyltransferase complex, serves as a novel master regulator that determines shoot stem cell fate in Arabidopsis through mediating m6A RNA modification and the resulting mRNA decay of key shoot meristem regulators. Our findings permit us to reveal the function of the m6A methyltransferase complex in sculpting the genome-wide m6A mRNA modification landscape in plants, and to further elucidate the concrete molecular link between m6A mRNA modification and plant development.